Peptide Nanofibers Preconditioned with Stem Cell Secretome Are Renoprotective

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Peptide nanofibers preconditioned with stem cell secretome are renoprotective.

Stem cells may contribute to renal recovery following acute kidney injury, and this may occur through their secretion of cytokines, chemokines, and growth factors. Here, we developed an acellular, nanofiber-based preparation of self-assembled peptides to deliver the secretome of embryonic stem cells (ESCs). Using an integrated in vitro and in vivo approach, we found that nanofibers precondition...

متن کامل

Effects of secretome obtained from normoxia-preconditioned human mesenchymal stem cells in traumatic brain injury rats.

BACKGROUND The aim of the present study was to investigate whether secretome obtained from normoxia-preconditioned human mesenchymal stem cells causes attenuation of traumatic brain injury (TBI), induced by fluid percussion injury. METHODS Anaesthetized male Sprague-Dawley rats, immediately after the onset of fluid percussion TBI, were divided into two major groups and given the vehicle solut...

متن کامل

Low pH preconditioned amniotic epithelial cells for stem cell therapy of cancer

Amniotic epithelial cells (AECs) possess unique characteristics, which make them a suitable source for cell-based therapeutic strategies. AECs have stem cell properties with low-immunogenicity (due to expressing HLA-G molecule and absence of MHC class I and II antigens) and no ethical problems, as well as availability in sufficient numbers, which can be obtained from a placenta. We have recentl...

متن کامل

A New Tool in Regenerative Medicine: Mesenchymal Stem Cell Secretome

Mesenchymal Stem Cells (MSCs), often referred to as stromal cells have been the focus in regenerative medicine for their immune suppressive ability, their ability to hone in on the site of injury, their ability to differentiate into multiple cell lines, and ease of cell culture expansion. MSCs have the ability to differentiate into a range of specialized cells of mesodermal origin bone, cartila...

متن کامل

The stem cell secretome and its role in brain repair

Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal (MSCs) and neural/progenitor stem cells (NPCs), exert a substantial beneficial and therapeutic effect after transplantation in experimental central nervous system (CNS) disease models through the secretion of immune modulatory or neurotrophic paracrine factors. This paracrine hypothesis has inspired an alternat...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 2011

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.2010040403